Article
Functional analysis reveals that RBM10 mutations contribute to lung adenocarcinoma pathogenesis by deregulating splicing.
Scientific reports - 16 Jan 2017
Zhao Jiawei, Sun Yue, Huang Yin, Song Fan, Huang Zengshu, Bao Yufang, Zuo Ji, Saffen David, Shao Zhen, Liu Wen, Wang Yongbo
Abstract excerpt
RBM10 is an RNA splicing regulator that is frequently mutated in lung adenocarcinoma (LUAD) and has recently been proposed to be a cancer gene. How RBM10 mutations observed in LUAD affect its normal functions, however, remains largely unknown. Here integrative analysis of RBM10 mutation and RNA expression data revealed that LUAD-associated RBM10 mutations exhibit a mutational spectrum similar to that of tumor...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.