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Article

The mutant p53-ID4 complex controls VEGFA isoforms by recruiting lncRNA MALAT1.

EMBO reports - 1 Aug 2017

Pruszko Magdalena, Milano Elisa, Forcato Mattia, Donzelli Sara, Ganci Federica, Di Agostino Silvia, De Panfilis Simone, Fazi Francesco, Bates David O, Bicciato Silvio, Zylicz Maciej, Zylicz Alicja, Blandino Giovanni, Fontemaggi Giulia

Abstract excerpt

The abundant, nuclear-retained, metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been associated with a poorly differentiated and aggressive phenotype of mammary carcinomas. This long non-coding RNA (lncRNA) localizes to nuclear speckles, where it interacts with a subset of splicing factors and modulates their activity. In this study, we demonstrate that oncogenic splicing factor SRSF1 bridges...

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Share to Gene Expression Regulation, Neoplastic
Share to Neovascularization, Pathologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Isoforms

Share to RNA, Long Noncoding

Share to RNA Splicing

Share to Serine-Arginine Splicing Factors

Share to Tumor Suppressor Protein p53

Share to Vascular Endothelial Growth Factor A

Source

Open in PubMed Open full text

Identifiers

PMID: 28652379
DOI: 10.15252/embr.201643370
PMCID: PMC5538427

Genes

VEGFA
SRSF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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