Associations between genetic variants in mRNA splicing-related genes and risk of lung cancer: a pathway-based analysis from published GWASs.

doi:10.1038/srep44634

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Article

Associations between genetic variants in mRNA splicing-related genes and risk of lung cancer: a pathway-based analysis from published GWASs.

Scientific reports - 17 Mar 2017

Pan Yongchu, Liu Hongliang, Wang Yanru, Kang Xiaozheng, Liu Zhensheng, Owzar Kouros, Han Younghun, Su Li, Wei Yongyue, Hung Rayjean J, Brhane Yonathan, McLaughlin John, Brennan Paul, Bickeböller Heike, Rosenberger Albert, Houlston Richard S, Caporaso Neil, Teresa Landi Maria, Heinrich Joachim, Risch Angela, Wu Xifeng, Ye Yuanqing, Christiani David C, Amos Christopher I, Wei Qingyi

Abstract excerpt

mRNA splicing is an important mechanism to regulate mRNA expression. Abnormal regulation of this process may lead to lung cancer. Here, we investigated the associations of 11,966 single-nucleotide polymorphisms (SNPs) in 206 mRNA splicing-related genes with lung cancer risk by using the summary data from six published genome-wide association studies (GWASs) of Transdisciplinary Research in Cancer of the Lung...

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PMID: 28304396
DOI: 10.1038/srep44634
PMCID: PMC5356340

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PRPF6
DHX16
LSM2

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