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Article

Oncogenic KRAS alters splicing factor phosphorylation and alternative splicing in lung cancer.

BMC cancer - 16 Dec 2022

Lo April, McSharry Maria, Berger Alice H

Abstract excerpt

BACKGROUND: Alternative RNA splicing is widely dysregulated in cancers including lung adenocarcinoma, where aberrant splicing events are frequently caused by somatic splice site mutations or somatic mutations of splicing factor genes. However, the majority of mis-splicing in cancers is unexplained by these known mechanisms. We hypothesize that the aberrant Ras signaling characteristic of lung cancers plays a role...

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Identifiers

PMID: 36522653
DOI: 10.1186/s12885-022-10311-1
PMCID: PMC9756471

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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