Article
RNA binding motif protein 10 suppresses lung cancer progression by controlling alternative splicing of eukaryotic translation initiation factor 4H.
EBioMedicine - 1 Nov 2020
Zhang Sirui, Bao Yufang, Shen Xianfeng, Pan Yunjian, Sun Yue, Xiao Man, Chen Kexuan, Wei Huanhuan, Zuo Ji, Saffen David, Zong Wei-Xing, Sun Yihua, Wang Zefeng, Wang Yongbo
Abstract excerpt
BACKGROUND: RNA splicing defects are emerging molecular hallmarks of cancer. The gene encoding splicing factor RNA binding motif protein 10 (RBM10) has been found frequently mutated in various types of cancer, particularly lung adenocarcinoma (LUAD), but how RBM10 affects cancer pathogenesis remains to be determined. Moreover, the functional roles and clinical significance of RBM10 mutation-associated splicing...
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