Article

Oncogenic KRAS alters splicing factor phosphorylation and alternative splicing in lung cancer

2022-05-20

Abstract excerpt

<h4>Background</h4> Alternative RNA splicing is widely dysregulated in cancers including lung adenocarcinoma, where aberrant splicing events are frequently caused by somatic splice site mutations or somatic mutations of splicing factor genes. However, the majority of mis-splicing in cancers is unexplained by these known mechanisms. We hypothesize that the aberrant Ras signaling characteristic of lung cancers play...

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Literature Corpus work: 60bbdcce-fef3-59b9-a3cd-8f71bf39ba97
DOI: 10.1101/2022.05.20.492866

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