Article
Co-occurrence of cohesin complex and Ras signaling mutations during progression from myelodysplastic syndromes to secondary acute myeloid leukemia.
Haematologica - 1 Aug 2021
Martín-Izquierdo Marta, Abáigar María, Hernández-Sánchez Jesús M, Tamborero David, López-Cadenas Félix, Ramos Fernando, Lumbreras Eva, Madinaveitia-Ochoa Andrés, Megido Marta, Labrador Jorge, Sánchez-Real Javier, Olivier Carmen, Dávila Julio, Aguilar Carlos, Rodríguez Juan N, Martín-Nuñez Guillermo, Santos-Mínguez Sandra, Miguel-García Cristina, Benito Rocío, Díez-Campelo María, Hernández-Rivas Jesús M
Abstract excerpt
Myelodysplastic syndromes (MDS) are hematological disorders at high risk of progression to secondary acute myeloid leukemia (sAML). However, the mutational dynamics and clonal evolution underlying disease progression are poorly understood at present. To elucidate the mutational dynamics of pathways and genes occurring during the evolution to sAML, next generation sequencing was performed on 84 serially paired...
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