Article
Lymphocyte DNA methylation mediates genetic risk at shared immune-mediated disease loci.
The Journal of allergy and clinical immunology - 1 May 2020
Clark Alexander D, Nair Nisha, Anderson Amy E, Thalayasingam Nishanthi, Naamane Najib, Skelton Andrew J, Diboll Julie, Barton Anne, Eyre Stephen, Isaacs John D, Pratt Arthur G, Reynard Louise N
Abstract excerpt
BACKGROUND: Defining regulatory mechanisms through which noncoding risk variants influence the cell-mediated pathogenesis of immune-mediated disease (IMD) has emerged as a priority in the post-genome-wide association study era. OBJECTIVES: With a focus on rheumatoid arthritis, we sought new insight into genetic mechanisms of adaptive immune dysregulation to help prioritize molecular pathways for targeting in this...
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