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PathGPS: discover shared genetic architecture using GWAS summary data.

Biometrics - 1 Jul 2024

Gao Zijun, Zhao Qingyuan, Hastie Trevor

Abstract excerpt

The increasing availability and scale of biobanks and "omic" datasets bring new horizons for understanding biological mechanisms. PathGPS is an exploratory data analysis tool to discover genetic architectures using Genome Wide Association Studies (GWAS) summary data. PathGPS is based on a linear structural equation model where traits are regulated by both genetic and environmental pathways. PathGPS decouples the...

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PMID: 39005072
DOI: 10.1093/biomtc/ujae060
PMCID: PMC11247175

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