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Article

Hierarchical structural component model for pathway analysis of common variants.

BMC medical genomics - 24 Feb 2020

Jiang Nan, Lee Sungyoung, Park Taesung

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) have been widely used to identify phenotype-related genetic variants using many statistical methods, such as logistic and linear regression. However, GWAS-identified SNPs, as identified with stringent statistical significance, explain just a small portion of the overall estimated genetic heritability. To address this 'missing heritability' issue, gene- and...

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Identifiers

PMID: 32093692
DOI: 10.1186/s12920-019-0650-0
PMCID: PMC7038534

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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