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Article

Uncovering the complex genetic architecture of human plasma lipidome using machine learning methods.

Scientific reports - 22 Feb 2023

Lehtimäki Miikael, Mishra Binisha H, Del-Val Coral, Lyytikäinen Leo-Pekka, Kähönen Mika, Cloninger C Robert, Raitakari Olli T, Laaksonen Reijo, Zwir Igor, Lehtimäki Terho, Mishra Pashupati P

Abstract excerpt

Genetic architecture of plasma lipidome provides insights into regulation of lipid metabolism and related diseases. We applied an unsupervised machine learning method, PGMRA, to discover phenotype-genotype many-to-many relations between genotype and plasma lipidome (phenotype) in order to identify the genetic architecture of plasma lipidome profiled from 1,426 Finnish individuals aged 30-45 years. PGMRA involves...

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Identifiers

PMID: 36813803
DOI: 10.1038/s41598-023-30168-z
PMCID: PMC9947228

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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