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Article

CoPheScan: phenome-wide association studies accounting for linkage disequilibrium.

Nature communications - 12 Jul 2024

Manipur Ichcha, Reales Guillermo, Sul Jae Hoon, Shin Myung Kyun, Longerich Simonne, Cortes Adrian, Wallace Chris

Abstract excerpt

Phenome-wide association studies (PheWAS) facilitate the discovery of associations between a single genetic variant with multiple phenotypes. For variants which impact a specific protein, this can help identify additional therapeutic indications or on-target side effects of intervening on that protein. However, PheWAS is restricted by an inability to distinguish confounding due to linkage disequilibrium (LD) from...

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Source

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Identifiers

PMID: 38997278
DOI: 10.1038/s41467-024-49990-8
PMCID: PMC11245513

Genes

APOE
TGM3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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