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Article

Genetic analyses identify pleiotropy and causality for blood proteins and highlight Wnt/β-catenin signalling in migraine.

Nature communications - 11 May 2022

Tanha Hamzeh M, Nyholt Dale R

Abstract excerpt

Migraine is a common complex disorder with a significant polygenic SNP heritability ([Formula: see text]). Here we utilise genome-wide association study (GWAS) summary statistics to study pleiotropy between blood proteins and migraine under the polygenic model. We estimate [Formula: see text] for 4625 blood protein GWASs and identify 325 unique proteins with a significant [Formula: see text] for use in subsequent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35546551
DOI: 10.1038/s41467-022-30184-z
PMCID: PMC9095680

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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