Article
Using Family History Data to Improve the Power of Association Studies: Application to Cancer in UK Biobank.
Genetic epidemiology - 1 Jan 2025
Wilcox Naomi, Tyrer Jonathan P, Dennis Joe, Yang Xin, Perry John R B, Gardner Eugene J, Easton Douglas F
Abstract excerpt
In large cohort studies the number of unaffected individuals outnumbers the number of affected individuals, and the power can be low to detect associations for outcomes with low prevalence. We consider how including recorded family history in regression models increases the power to detect associations between genetic variants and disease risk. We show theoretically and using Monte-Carlo simulations that...
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