Article

CoPheScan: phenome-wide association studies accounting for linkage disequilibrium

2023-06-29

Abstract excerpt

Phenome-wide association studies (PheWAS) facilitate the discovery of associations between a single genetic variant with multiple phenotypes. For variants which impact a specific protein, this can help identify additional therapeutic indications or on-target side effects of intervening on that protein. However, PheWAS is restricted by an inability to distinguish confounding due to linkage disequilibrium (LD) from...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f4e2dd75-0502-5a30-a51e-cc82ba80232a
DOI: 10.1101/2023.06.29.546856

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CoPheScan: phenome-wide association studies accounting for linkage disequilibriumDOI 10.1101/2023.06.29.546856Read

CoPheScan: phenome-wide association studies accounting for linkage disequilibrium.Semantic proximity Read

Genome-wide pQTL mapping in human skin identifies specific genetic regulators and mechanistic links to skin disordersSemantic proximity Read

GhostKnockoff inference empowers identification of putative causal variants in genome-wide association studies.Semantic proximity Read

Probabilistic Fine-mapping of Putative Causal GenesSemantic proximity Read

Summary statistics knockoff inference empowers identification of putative causal variants in genome-wide association studiesSemantic proximity Read

Genetic analyses identify pleiotropy and causality for blood proteins and highlight Wnt/β-catenin signalling in migraine.Semantic proximity Read

Using Family History Data to Improve the Power of Association Studies: Application to Cancer in UK BiobankSemantic proximity Read

PhenoScanner: a database of human genotype-phenotype associations.Semantic proximity Read

Whole exome sequencing in 75 high-risk families with validation and replication in independent case-control studies identifies TANGO2, OR5H14, and CHAD as new prostate cancer susceptibility genes.Semantic proximity Read

Primo: integration of multiple GWAS and omics QTL summary statistics for elucidation of molecular mechanisms of trait-associated SNPs and detection of pleiotropy in complex traits.Semantic proximity Read

PhenoExplorer: An Interactive Web-based Platform for Exploring (Epi)Genome-Wide Associations Using a Swiss Population-based Study.Semantic proximity Read

Using Family History Data to Improve the Power of Association Studies: Application to Cancer in UK Biobank.Semantic proximity Read