Article
Genome-wide pQTL mapping in human skin identifies specific genetic regulators and mechanistic links to skin disorders.
Nature communications - 15 Aug 2026
Sun Yuanqiang, Li Wenchao, Wang Zhenzhen, Yang Yongliang, Zhang Ziyang, Yu Gongqi, Wang Chuan, Sang Xu, Lin Yingjie, Zhang Guangliang, Wang Haixia, Wu Yilei, Wang Jianwen, Bai Fuxiang, Liu Jianju, Liu Hong, Zhang Furen
Abstract excerpt
Understanding how genetic variation shapes tissue-specific protein expression is fundamental for uncovering disease mechanisms and therapeutic targets. However, the proteomic landscape and its underlying genetic regulation in skin, the largest human organ, remain largely uncharted. Here, we present a population-level skin proteomic dataset, quantifying 5,774 proteins across 248 individuals and revealing...
Read the complete abstract on PubMedTopics
- Humans
- Genome-Wide Association Study
- Quantitative Trait Loci
- Skin
- Genetic Predisposition to Disease