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Single-Cell RNA Sequencing Technology Revealed the Pivotal Role of Fibroblast Heterogeneity in Angiotensin II-Induced Abdominal Aortic Aneurysms

22 Apr 2022

Abstract excerpt

The mechanism of abdominal aortic aneurysm (AAA) has not been fully elucidated. In this study, we aimed to map the cellular heterogeneity, molecular alteration, and functional transformation of angiotensin (Ang) II-induced AAA in mice based on single-cell RNA sequencing (sc-RNA seq) technology. sc-RNA seq was performed on suprarenal abdominal aorta tissue from male Apoe−/− C57BL/6 mice of Ang II-induced AAA and...

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Aortic aneurysm repair treatments
Aortic Disease and Treatment Approaches

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35451888
DOI: 10.1089/dna.2021.0923

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