SLC44A2-mediated phenotypic switch of vascular smooth muscle cells contributes to aortic aneurysm.

Abstract excerpt

The phenotypic switch of vascular smooth cells (VSMCs) from a contractile to a synthetic state is associated with the development and progression of aortic aneurysm (AA). However, the mechanism underlying this process remains unclear. In this issue of the JCI, Song et al. identified SLC44A2 as a regulator of the phenotypic switch in VSMCs. Inhibition of SLC44A2 facilitated the switch to the synthetic state,...

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• Aortic Aneurysm
• Integrin beta3
• Membrane Transport Proteins
• Muscle, Smooth, Vascular
• Myocytes, Smooth Muscle