Mutational activation of H-ras oncogene transformability by alkylnitrosourea-induced DNA damage.

doi:10.1016/0027-5107(92)90192-5

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Article

Mutational activation of H-ras oncogene transformability by alkylnitrosourea-induced DNA damage.

Mutation research - 1 Apr 1992

Yamasaki E F, Salamon D P, Wani A A

Abstract excerpt

To assess the role of DNA alkylation damage in oncogene activation, plasmid DNA containing H-ras proto-oncogene (p220-EC) and oncogene (p220-EJ) were treated with increasing concentrations of carcinogenic methylnitrosourea (MNU) and ethylnitrosourea (ENU). The modified plasmid DNA were analyzed b...

Topics

3T3 Cells
Alkylation
Animals
Base Sequence
Cell Transformation, Neoplastic
DNA
DNA Damage
Ethylnitrosourea
Gene Expression Regulation
Genes, ras
Methylnitrosourea
Mice
Molecular Sequence Data
Mutation

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