Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats.

doi:10.1038/315382a0

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Article

Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats.

Nature - 1 Jan 2000

Zarbl H, Sukumar S, Arthur A V, Martin-Zanca D, Barbacid M

Abstract excerpt

Induction of mammary carcinomas in rats by a single exposure to a carcinogen during sexual development often involves malignant activation of the Ha-ras-1 locus. Each of the Ha-ras-1 oncogenes present in tumours induced by N-nitroso-N-methylurea, but not in those induced by 7,12-dimethylbenz(a)an...

Topics

9,10-Dimethyl-1,2-benzanthracene
Animals
Base Sequence
Female
Mammary Neoplasms, Experimental
Methylnitrosourea
Mutation
Nitrosourea Compounds
Oncogenes
Rats

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