[Metabolic activation of carcinogenic N-nitrosodialkylamines].

Abstract excerpt

Chemical and biological properties of metabolically activated species of carcinogenic N-nitrosodialkylamines are reviewed. alpha-Hydroxy nitrosamines and their derivatives; alpha-acetoxy nitrosamines, alpha-hydroperoxy nitrosamines, alpha-phosphonooxy nitrosamines and alkanediazotates are included. Metabolic deactivation through denitrosation and metabolic activation through beta-oxidation are also mentioned.

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