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Multiplexing Imaging of Closely Located Single-Nucleotide Mutations in Single Cells via Encoded in situ PCR.

ACS sensors - 26 Jul 2024

Ren Yao, Liu Kerui, Yang Hao, Zhang Yong, Deng Sha, Cao Jijuan, Xia Xuhan, Deng Ruijie

Abstract excerpt

Mutation accumulation in RNAs results in closely located single-nucleotide mutations (SNMs), which is highly associated with the drug resistance of pathogens. Imaging of SNMs in single cells has significance for understanding the heterogeneity of RNAs that are related to drug resistance, but the direct "see" closely located SNMs remains challenging. Herein, we designed an encoded ligation-mediated in situ...

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PMID: 38982583
DOI: 10.1021/acssensors.4c00378

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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