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Article

Single-Cell Genotyping of Single-Nucleotide Mutations Using In Situ Allele-Specific Loop-Mediated Isothermal Amplification.

ACS sensors - 24 Nov 2023

Yuan Zilan, Liu Xinmiao, Deng Sha, He Guiping, Zhang Jiaqi, He Qiang, Chi Yuanlong, Jiang Xiue, Xia Xuhan, Deng Ruijie

Abstract excerpt

Single-nucleotide mutations (SNMs) in the bacterial genome may cause antibiotic resistance. The visualization of SNMs can indicate antibiotic resistance phenotypes at the single-cell level but remains challenging. Herein, we proposed an in situ allele-specific isothermal amplification proceeded inside cells, allowing us to image bacterial genes with single-nucleotide resolution. The primer for loop-mediated...

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PMID: 37862679
DOI: 10.1021/acssensors.3c01679

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