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Article

Lighting up single-nucleotide variation in situ in single cells and tissues.

Chemical Society reviews - 23 Mar 2020

Zhang Kaixiang, Deng Ruijie, Gao Hua, Teng Xucong, Li Jinghong

Abstract excerpt

The ability to 'see' genetic information directly in single cells can provide invaluable insights into complex biological systems. In this review, we discuss recent advances of in situ imaging technologies for visualizing the subtlest sequence alteration, single-nucleotide variation (SNV), at single-cell level. The mechanism of recently developed methods for SNV discrimination are summarized in detail. With...

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PMID: 32108196
DOI: 10.1039/c9cs00438f

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