Article
On-chip ligation of multiplexing probe-pairs for identifying point mutations out of dense SNP loci.
Biosensors & bioelectronics - 1 Dec 2008
Xu Chao, Zhou Ya-Feng, Deng Jiao-Yu, Deng Xiang, Guo Yong-Chao, Cui Zong-Qiang, Zhang Zhi-Ping, Wei Hong-Ping, Bi Li-Jun, Zhang Xian-En
Abstract excerpt
Detailed analyses of dense single nucleotide polymorphism (SNP) loci within rifampin-resistance determining region (RRDR) are very important for the early assessment of drug resistance of Mycobacterium tuberculosis. A strategy was developed here to specifically identify point mutations out of dense SNP loci by on-chip ligation of multiplexing probe-pairs (MPPs). A probe-pair combines a common probe with a...
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