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Network-based Plasma Proteomics Reveals Molecular Overlap Between Physical Activity and Dementia Risk

2025-03-10

Abstract excerpt

Physical activity (PA) is linked to lower dementia risk, but molecular pathways underpinning PA-related dementia risk are poorly understood. We conducted plasma proteomics (SomaScan v4.1) and 30-day Fitbit-based PA monitoring (average daily step count) in 65 cognitively unimpaired older adults from the UCSF BrANCH cohort. Differential regression and network analyses identified PA plasma proteomic signatures tied t...

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Identifiers and source

Literature Corpus work
f6a0f039-846b-598f-a6d1-f9c3cdfd0218
DOI
10.1101/2025.03.07.25323587
Open publication

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Network-based Plasma Proteomics Reveals Molecular Overlap Between Physical Activity and Dementia RiskDOI 10.1101/2025.03.07.25323587
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