Article
Genome and epigenome wide studies of plasma protein biomarkers for Alzheimer’s disease implicate TBCA and TREM2 in disease risk
2021-06-10
Abstract excerpt
The levels of many blood proteins are associated with Alzheimer’s disease or its pathological hallmarks. Elucidating the molecular factors that control circulating levels of these proteins may help to identify proteins causally associated with the disease. Here, genome-wide and epigenome-wide studies (n individuals ≤1,064) were performed on plasma levels of 281 Alzheimer’s disease-associated proteins, identified b...
Topics
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- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Immune cells in cancer
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Phosphodiesterase function and regulation
- Tryptophan and brain disorders
Identifiers and source
- Literature Corpus work
- c3415eb3-efac-58a8-b332-359f5cdd11f5
- DOI
- 10.1101/2021.06.07.21258457