Article
Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation.
PLoS genetics - 1 Oct 2014
Kauwe John S K, Bailey Matthew H, Ridge Perry G, Perry Rachel, Wadsworth Mark E, Hoyt Kaitlyn L, Staley Lyndsay A, Karch Celeste M, Harari Oscar, Cruchaga Carlos, Ainscough Benjamin J, Bales Kelly, Pickering Eve H, Bertelsen Sarah, Fagan Anne M, Holtzman David M, Morris John C, Goate Alison M
Abstract excerpt
Cerebrospinal fluid (CSF) 42 amino acid species of amyloid beta (Aβ42) and tau levels are strongly correlated with the presence of Alzheimer's disease (AD) neuropathology including amyloid plaques and neurodegeneration and have been successfully used as endophenotypes for genetic studies of AD. Additional CSF analytes may also serve as useful endophenotypes that capture other aspects of AD pathophysiology. Here...
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