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Article

Conditioned culture medium of bone marrow mesenchymal stem cells promotes phenotypic transformation of microglia by regulating mitochondrial autophagy.

PeerJ - 1 Jan 2024

Ji Hangyu, Chu Weiming, Yang Yong, Peng Xin, Song Xiaoli

Abstract excerpt

Objective: To study the mechanism by which conditioned medium of bone marrow mesenchymal stem cells (BMSCs-CM) facilitates the transition of pro-inflammatory polarized microglia to an anti-inflammatory phenotype. Methods: BV2 cells, a mouse microglia cell line, were transformed into a pro-inflammatory phenotype using lipopolysaccharide. The expression of phenotypic genes in BV2 cells was detected using real-time...

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Identifiers

PMID: 38974415
DOI: 10.7717/peerj.17664
PMCID: PMC11227809

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