Article

Umbilical cord-derived mesenchymal stromal cells immunomodulate and restore actin dynamics and phagocytosis of LPS-activated microglia via PI3K/Akt/Rho GTPase pathway

2020-06-16

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Microglia are the immune cells in the central nervous system constantly surveying their environment and reacting to various injuries. Activated microglia may cause impaired synaptic plasticity, therefore modulating and restoring them to more neutral phenotype is crucial to counteract a pro-inflammatory, neurotoxic state. In this study, we focused on elucidating...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 076d336b-12b3-5663-8101-af2593281355
DOI: 10.21203/rs.3.rs-28768/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Umbilical cord-derived mesenchymal stromal cells immunomodulate and restore actin dynamics and phagocytosis of LPS-activated microglia via PI3K/Akt/Rho GTPase pathwayDOI 10.21203/rs.3.rs-28768/v1Read

Modulating the polarization phenotype of microglia - A valuable strategy for central nervous system diseases.Semantic proximity Read

Exploring New Inflammatory Biomarkers and Pathways during LPS-Induced M1 Polarization.Semantic proximity Read

Microglia dynamic response and phenotype heterogeneity in neural regeneration following hypoxic-ischemic brain injury.Semantic proximity Read

The tri-culture system reveals an activation cascade from microglia through astrocytes to neurons during neuroinflammationSemantic proximity Read

MicrogliaSemantic proximity Read

Research Progress on Treating Spinal Cord Injury by Modulating the Phenotype of Microglia.Semantic proximity Read

Human umbilical cord mesenchymal stem cells alleviate white-matter injury by regulating polarization of microgliaSemantic proximity Read

A unique hybrid characteristic having both pro- and anti-inflammatory phenotype transformed by repetitive low-dose lipopolysaccharide in C8-B4 microglia.Semantic proximity Read

Microglia/macrophage polarization: Fantasy or evidence of functional diversity?Semantic proximity Read

Astrocyte Stimulates Microglial Proliferation and M2 Polarization <em>in vitro</em> through Cross-Talk between Astrocyte and MicrogliaSemantic proximity Read

Effects of the pig renal epithelial cell line LLC-PK1 and its conditioned medium on the phenotype of porcine microglia in vitro.Semantic proximity Read

Phenotyping primary human microglia: tight regulation of LPS responsiveness.Semantic proximity Read