Article
Bone marrow-derived mesenchymal stem cells maintain the resting phenotype of microglia and inhibit microglial activation.
PloS one - 1 Jan 2013
Yan Ke, Zhang Run, Sun Chengmei, Chen Lei, Li Peng, Liu Yi, Peng Lingmei, Sun Haitao, Qin Kun, Chen Fanfan, Huang Weiyi, Chen Yuxin, Lv Bingke, Du Mouxuan, Zou Yuxi, Cai Yingqian, Qin Lingsha, Tang Yanping, Jiang Xiaodan
Abstract excerpt
Many studies have shown that microglia in the activated state may be neurotoxic. It has been proven that uncontrolled or over-activated microglia play an important role in many neurodegenerative disorders. Bone marrow-derived mesenchymal stem cells (BMSCs) have been shown in many animal models to have a therapeutic effect on neural damage. Such a therapeutic effect is attributed to the fact that BMSCs have the...
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