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Astrocyte-derived exosomes enriched with miR-873a-5p inhibit neuroinflammation via microglia phenotype modulation after traumatic brain injury.

Journal of neuroinflammation - 19 Mar 2020

Long Xiaobing, Yao Xiaolong, Jiang Qian, Yang Yiping, He Xuejun, Tian Weidong, Zhao Kai, Zhang Huaqiu

Abstract excerpt

BACKGROUND: The interaction between astrocytes and microglia plays a vital role in the damage and repair of brain lesions due to traumatic brain injury (TBI). Recent studies have shown that exosomes act as potent mediators involved in intercellular communication. METHODS: In the current study, the expression of inflammatory factors and miR-873a-5p in the lesion area and oedema area was evaluated in 15 patients...

Topics

Animals
Astrocytes
Brain Injuries, Traumatic
Cell Communication
Exosomes
Humans
Inflammation
Male
Mice
Mice, Inbred C57BL
MicroRNAs

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microglia

Phenotype

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Identifiers

PMID: 32192523
DOI: 10.1186/s12974-020-01761-0
PMCID: PMC7082961

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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