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Article

Polymorphic regulation of mitochondrial fission and fusion modifies phenotypes of microglia in neuroinflammation.

Scientific reports - 10 Jul 2017

Katoh Mitsuhiko, Wu Bao, Nguyen Huy Bang, Thai Truc Quynh, Yamasaki Ryo, Lu Haiyan, Rietsch Anna M, Zorlu Musab M, Shinozaki Youichi, Saitoh Yurika, Saitoh Sei, Sakoh Takashi, Ikenaka Kazuhiro, Koizumi Schuichi, Ransohoff Richard M, Ohno Nobuhiko

Abstract excerpt

Microglia are the resident macrophages of the central nervous system and play complex roles in the milieu of diseases including the primary diseases of myelin. Although mitochondria are critical for cellular functions and survival in the nervous system, alterations in and the roles of mitochondrial dynamics and associated signaling in microglia are still poorly understood. In the present study, by combining...

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Identifiers

PMID: 28694451
DOI: 10.1038/s41598-017-05232-0
PMCID: PMC5503944

Genes

TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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