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Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Pro-Inflammatory Macrophage Polarization: Comparison of Matrix-Bound and Small Extracellular Vesicles.

Cells - 6 Jan 2026

Klyucherev Timofey O, Yurkanova Maria D, Revokatova Daria P, Chevalier Dmitriy A, Shishkov Vsevolod V, Vlasova Irina I, Kosheleva Nastasia V, Timashev Peter S

Abstract excerpt

Macrophages play a crucial role in regulating immune responses, inflammation, and tissue repair. Depending on environmental cues, they polarize into pro-inflammatory M1 or anti-inflammatory, pro-regenerative M2 phenotypes. Extracellular vesicles (EVs) derived from mesenchymal stem/stromal cells (MSCs) have emerged as key mediators of intercellular communication and immune modulation. This study investigates the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41597169
DOI: 10.3390/cells15020093
PMCID: PMC12838643

Genes

STAT1
CD86
CXCL10
STAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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