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Article

Incorporating both genetic and tobacco smoking data to identify high-risk smokers for lung cancer screening.

Carcinogenesis - 21 Jun 2021

Jia Guochong, Wen Wanqing, Massion Pierre P, Shu Xiao-Ou, Zheng Wei

Abstract excerpt

The US Preventive Services Task Force (USPSTF) recently proposed to widen the current lung cancer screening guideline to include less-heavy smokers. We sought to incorporate both genetic and tobacco smoking data to evaluate the proposed new guideline in white smokers. We constructed a polygenic risk score (PRS) using lung cancer risk variants. Using data from 308 490 participants of European descent in the UK...

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Identifiers

PMID: 33640962
DOI: 10.1093/carcin/bgab018
PMCID: PMC8215593

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