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Article

The shared genetic architecture between epidemiological and behavioral traits with lung cancer.

Scientific reports - 2 Sept 2021

Pettit Rowland W, Byun Jinyoung, Han Younghun, Ostrom Quinn T, Edelson Jacob, Walsh Kyle M, Bondy Melissa L, Hung Rayjean J, McKay James D, Amos Christopher I

Abstract excerpt

The complex polygenic nature of lung cancer is not fully characterized. Our study seeks to identify novel phenotypes associated with lung cancer using cross-trait linkage disequilibrium score regression (LDSR). We measured pairwise genetic correlation (rg) and SNP heritability (h2) between 347 traits and lung cancer risk using genome-wide association study summary statistics from the UKBB and OncoArray...

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Identifiers

PMID: 34475455
DOI: 10.1038/s41598-021-96685-x
PMCID: PMC8413319

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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