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Article

Assessing a Polygenic Risk Score for Lung Cancer Susceptibility in Non-Hispanic White and Black Populations.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Nov 2023

Trendowski Matthew R, Lusk Christine M, Wenzlaff Angela S, Neslund-Dudas Christine, Gadgeel Shirish M, Soubani Ayman O, Schwartz Ann G

Abstract excerpt

BACKGROUND: Polygenic risk scores (PRS) have become an increasingly popular approach to evaluate cancer susceptibility, but have not adequately represented Black populations in model development. METHODS: We used a previously published lung cancer PRS on the basis of 80 SNPs associated with lung cancer risk in the OncoArray cohort and validated in UK Biobank. The PRS was evaluated for association with lung cancer...

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Identifiers

PMID: 37578347
DOI: 10.1158/1055-9965.EPI-23-0174
PMCID: PMC10841320

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