Article
Identification of risk loci and a polygenic risk score for lung cancer: a large-scale prospective cohort study in Chinese populations.
The Lancet. Respiratory medicine - 1 Oct 2019
Dai Juncheng, Lv Jun, Zhu Meng, Wang Yuzhuo, Qin Na, Ma Hongxia, He Yong-Qiao, Zhang Ruoxin, Tan Wen, Fan Jingyi, Wang Tianpei, Zheng Hong, Sun Qi, Wang Lijuan, Huang Mingtao, Ge Zijun, Yu Canqing, Guo Yu, Wang Tong-Min, Wang Jie, Xu Lin, Wu Weibing, Chen Liang, Bian Zheng, Walters Robin, Millwood Iona Y, Li Xi-Zhao, Wang Xin, Hung Rayjean J, Christiani David C, Chen Haiquan, Wang Mengyun, Wang Cheng, Jiang Yue, Chen Kexin, Chen Zhengming, Jin Guangfu, Wu Tangchun, Lin Dongxin, Hu Zhibin, Amos Christopher I, Wu Chen, Wei Qingyi, Jia Wei-Hua, Li Liming, Shen Hongbing
Abstract excerpt
BACKGROUND: Genetic variation has an important role in the development of non-small-cell lung cancer (NSCLC). However, genetic factors for lung cancer have not been fully identified, especially in Chinese populations, which limits the use of existing polygenic risk scores (PRS) to identify subpopulations at high risk of lung cancer for prevention. We therefore aimed to identify novel loci associated with NSCLC...
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