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Article

Inducible deletion of the prostaglandin EP3 receptor in kidney tubules of male and female mice has no major effect on water homeostasis.

American journal of physiology. Renal physiology - 1 Sept 2024

Esteva-Font Cristina, Geurts Frank, Hansen Toke P K, Hoorn Ewout J, Fenton Robert A

Abstract excerpt

The prostaglandin E2 (PGE2) receptor EP3 has been detected in the thick ascending limb (TAL) and the collecting duct of the kidney, where its actions are proposed to inhibit water reabsorption. However, EP3 is also expressed in other cell types, including vascular endothelial cells. The aim here was to determine the contribution of EP3 in renal water handling in male and female adult mice by phenotyping a novel...

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Identifiers

PMID: 38961846
DOI: 10.1152/ajprenal.00146.2024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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