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Article

Heterozygous Mutation of Vegfr3 Reduces Renal Lymphatics without Renal Dysfunction.

Journal of the American Society of Nephrology : JASN - 1 Dec 2021

Liu Hao, Hiremath Chitkale, Patterson Quinten, Vora Saumya, Shang Zhiguo, Jamieson Andrew R, Fiolka Reto, Dean Kevin M, Dellinger Michael T, Marciano Denise K

Abstract excerpt

BACKGROUND: Lymphatic abnormalities are observed in several types of kidney disease, but the relationship between the renal lymphatic system and renal function is unclear. The discovery of lymphatic-specific proteins, advances in microscopy, and available genetic mouse models provide the tools to help elucidate the role of renal lymphatics in physiology and disease. METHODS: We utilized a mouse model containing a...

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Identifiers

PMID: 34551997
DOI: 10.1681/ASN.2021010061
PMCID: PMC8638391

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