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Article

Prostaglandin-E2 Mediated Increase in Calcium and Phosphate Excretion in a Mouse Model of Distal Nephron Salt Wasting.

PloS one - 1 Jan 2016

Soleimani Manoocher, Barone Sharon, Xu Jie, Alshahrani Saeed, Brooks Marybeth, McCormack Francis X, Smith Roger D, Zahedi Kamyar

Abstract excerpt

Contribution of salt wasting and volume depletion to the pathogenesis of hypercalciuria and hyperphosphaturia is poorly understood. Pendrin/NCC double KO (pendrin/NCC-dKO) mice display severe salt wasting under basal conditions and develop profound volume depletion, prerenal renal failure, and metabolic alkalosis and are growth retarded. Microscopic examination of the kidneys of pendrin/NCC-dKO mice revealed the...

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Identifiers

PMID: 27442254
DOI: 10.1371/journal.pone.0159804
PMCID: PMC4956050

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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