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Article

Collecting duct-specific knockout of the endothelin A receptor alters renal vasopressin responsiveness, but not sodium excretion or blood pressure.

American journal of physiology. Renal physiology - 1 Oct 2005

Ge Yuqiang, Stricklett Peter K, Hughes Alisa K, Yanagisawa Masashi, Kohan Donald E

Abstract excerpt

Collecting duct (CD)-specific knockout (KO) of endothelin-1 (ET-1) causes hypertension, impaired ability to excrete a Na load, and enhanced CD sensitivity to the hydrosmotic effects of vasopressin (AVP). CD express the two known ET receptors, ET(A) and ET(B); in the current study, the role of the CD ET(A) receptor in mediating ET-1 actions on this nephron segment was evaluated. The ET(A) receptor gene was...

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Identifiers

PMID: 15928212
DOI: 10.1152/ajprenal.00100.2005

Genes

AVP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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