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Article

Nephrogenic diabetes insipidus in mice lacking aquaporin-3 water channels.

Proceedings of the National Academy of Sciences of the United States of America - 11 Apr 2000

Ma T, Song Y, Yang B, Gillespie A, Carlson E J, Epstein C J, Verkman A S

Abstract excerpt

Aquaporin-3 (AQP3) is a water channel expressed at the basolateral plasma membrane of kidney collecting-duct epithelial cells. The mouse AQP3 cDNA was isolated and encodes a 292-amino acid water/glycerol-transporting glycoprotein expressed in kidney, large airways, eye, urinary bladder, skin, and gastrointestinal tract. The mouse AQP3 gene was analyzed, and AQP3 null mice were generated by targeted gene...

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Topics

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Share to Amino Acid Sequence
Share to Aquaporins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Deamino Arginine Vasopressin

Share to Diabetes Insipidus, Nephrogenic

Share to DNA, Complementary

Share to Mice, Inbred C57BL

Share to Mice, Knockout

Share to Sequence Homology, Amino Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 10737773
DOI: 10.1073/pnas.080499597
PMCID: PMC18251

Genes

AQP3
AQP4
AQP1
AQP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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