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Article

Salt supplementation ameliorates developmental kidney defects in COX-2-/- mice.

American journal of physiology. Renal physiology - 1 Jun 2017

Slattery Patrick, Frölich Stefanie, Goren Itamar, Nüsing Rolf M

Abstract excerpt

Deficiency of cyclooxygenase-2 (COX-2) activity in the early postnatal period causes impairment of kidney development leading to kidney insufficiency. We hypothesize that impaired NaCl reabsorption during the first days of life is a substantial cause for nephrogenic defects observed in COX-2-/- mice and that salt supplementation corrects these defects. Daily injections of NaCl (0.8 mg·g-1·day-1) for the first 10...

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Share to Potassium Channels, Inwardly Rectifying

Share to Sodium Chloride, Dietary

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Source

Identifiers

PMID: 28274925
DOI: 10.1152/ajprenal.00565.2016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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