Article

Epistasis and background dependence in the evolution of Omicron variants of the SARS-CoV-2 Spike protein

2025-11-19

Abstract excerpt

The rapid and repeated emergence of SARS-CoV-2 variants, particularly within the Omicron lineage, highlights the remarkable ability of the virus to adapt under shifting immune pressures. A central molecular battleground in this evolutionary arms race is the spike receptor-binding domain (RBD), which must simultaneously maintain high affinity for the human ACE2 receptor while evading recognition by neutralizing ant...

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Literature Corpus work: 72987816-9d12-5877-95c9-20dd2053609c
DOI: 10.1101/2025.11.18.689118

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