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Article

Evidence for lineage continuity between early serous proliferations (ESPs) in the Fallopian tube and disseminated high-grade serous carcinomas.

The Journal of pathology - 1 Nov 2018

Soong Thing Rinda, Howitt Brooke E, Miron Alexander, Horowitz Neil S, Campbell Frank, Feltmate Colleen M, Muto Michael G, Berkowitz Ross S, Nucci Marisa R, Xian Wa, Crum Christopher P

Abstract excerpt

The distal Fallopian tube is a site of origin for many 'ovarian' high-grade serous carcinomas (HGSCs) with intraepithelial carcinomas (STICs) that share identical TP53 mutations with metastatic tumors. TP53 mutation-positive early serous proliferations (ESPs) comprise a spectrum including p53 signatures and serous tubal intraepithelial lesions (STILs) and are not considered malignant; however, ESPs are often the...

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Identifiers

PMID: 30043522
DOI: 10.1002/path.5145

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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