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Article

Llama Nanoantibodies with Therapeutic Potential against Human Norovirus Diarrhea

12 Aug 2015

Abstract excerpt

Noroviruses are a major cause of acute gastroenteritis, but no vaccines or therapeutic drugs are available. Llama-derived single chain antibody fragments (also called VHH) are small, recombinant monoclonal antibodies of 15 kDa with several advantages over conventional antibodies. The aim of this study was to generate recombinant monoclonal VHH specific for the two major norovirus (NoV) genogroups (GI and GII) in...

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PMID: 26267898
DOI: 10.1371/journal.pone.0133665

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