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Article

Nanobody Binding to a Conserved Epitope Promotes Norovirus Particle Disassembly

18 Dec 2014

Abstract excerpt

UNLABELLED: Human noroviruses are icosahedral single-stranded RNA viruses. The capsid protein is divided into shell (S) and protruding (P) domains, which are connected by a flexible hinge region. There are numerous genetically and antigenically distinct noroviruses, and the dominant strains evolve every other year. Vaccine and antiviral development is hampered by the difficulties in growing human norovirus in...

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PMID: 25520510
DOI: 10.1128/jvi.03176-14

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