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Article

Nanobody-Mediated Neutralization Reveals an Achilles Heel for Norovirus

21 Apr 2020

Abstract excerpt

This research discovered and analyzed two different types of MNV-neutralizing nanobodies. The top-binding nanobodies sterically inhibited the receptor-binding site, whereas the dimeric-binding nanobodies interfered with a structural modification associated with cofactor binding. Moreover, we found that the capsid contained a number of vulnerable regions that were essential for viral replication. In fact, the...

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PMID: 32321816
DOI: 10.1128/jvi.00660-20

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