Article

Progress in the Development of Broadly Reactive Norovirus Therapeutics

2024-02-26

Abstract excerpt

Discovered over five decades ago, norovirus is frequently reported as the leading cause of outbreaks of acute gastroenteritis. No vaccines or antivirals are currently available. We further analyzed two of our leading norovirus inhibitors that either indirectly or directly obstructed norovirus from binding to histo-blood group antigen receptors. Using X-ray crystallography, we showed that both inhibitors engage hig...

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Identifiers and source

Literature Corpus work: 8c99d129-91c4-530c-b0c5-c1797a9bce93
DOI: 10.21203/rs.3.rs-3980499/v1

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